Total synthesis of insulin-like growth factor I (somatomedin C).
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چکیده
منابع مشابه
Somatomedin C/insulin-like growth factor I levels after treatment of acromegaly.
An in-house method was used, including dissociation of Somatomedin C/insulin-like Growth Factor I (Sm-C/IGF-I) binding proteins with acid and extraction of Sm-C/IGF-I by C-2 cartridge before radioimmunoassay, to measure plasma Sm-C/IGF-I levels in three groups of patients--total of 19--with acromegaly who underwent transsphenoidal removal of pituitary tumors. In group A (n = 7), the Sm-C/IGF-I ...
متن کاملEnhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor I/somatomedin C and human growth hormone.
The effect of biosynthetic recombinant insulin-like growth factor I/somatomedin C (IGF-I/Sm-C) and human growth hormone (hGH) on the in vitro growth and maturation of human marrow myeloid progenitors was investigated. Myeloid colony formation was maximally enhanced by 60 ng/ml IGF-I/Sm-C and by 250 ng/ml hGH, resulting in an increase in colony numbers of 41 +/- 7 and 38 +/- 4%, respectively (P ...
متن کاملInsulin-like Growth Factor I1 Binding to the Type I Somatomedin Receptor
We have previously shown that the antireceptor antibody aIR-3 inhibits binding of '2SI-somatomedin-C/ insulin-like growth factor I (Sm-C/IGF-I) to the 130kDa a subunit of the type I receptor in human placental membranes, but does not block 121-insulin-like growth factor I1 (IGF-11) binding to a similar 130-kDa complex in these membranes. To determine whether the 130kDa '281-IGF-II binding compl...
متن کاملEvidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors.
Immunoreactive somatomedin-C/insulin-like growth factor I (SM-C/IGF I) content was measured in human neoplastic lung tissue obtained from surgery on 10 patients (seven epidermoid carcinoma, three adenocarcinoma), and in normal lung tissue obtained from the same excised portion. SM-C/IGF I content in lung tumors was 615 +/- 123 (SE) milliunits/g of tissue (range, 214-1531), significantly higher ...
متن کاملInsulin-like growth factor I gene polymorphism associated with growth traits in beluga (Huso huso) fish
The aim of the present study was to detect polymorphism in Insulin like growth factor-I (IGF-I) gene of beluga (Huso huso) fish using PCR-SSCP technique and also investigation of its association with growth traits (condition factor, body length and weight). A total of 150 specimens of beluga were randomly selected and DNA was isolated from caudal fin using modified salting out method. Then two ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.8.2216